Dominguez Thaysen

Unfractionated heparin (UFH) therapy is monitored by using the anti-Xa activity, or the aPTT, which remains the most widely used assay. One of the main advantages of anti-Xa relies on its hypothesized standardization, with a unique therapeutic range (0.30-0.70 IU/mL) for all reagents, whereas aPTT is influenced by numerous preanalytical and…[Read more]

The interaction between TTO and azoles was evaluated through the checkerboard and isobologram methods. The results demonstrated both the fungicide activity of TTO on T. rubrum and the synergism when it was used in combination with azoles. Therefore, this mixture may reduce the minimum effective dose of azole required and minimize the side effects…[Read more]

Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response Box against Plasmodium asexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides.…[Read more]

The test DWTP with a pulse clarification system was having comparable microplastics removal efficiency with previously reported advanced DWTPs.The global population growth demands intensification of anthropogenic processes, thus leading to inter alia pollution of both land and aquatic environments with toxic organic compounds. Particularly harmful…[Read more]

This study investigated the potential role of quantitative ultrasound (QUS) to assess low bone mass in anorexia nervosa patients (AN). Bone parameters from QUS and DXA were positively correlated and significantly reduced in AN compared with controls, suggesting that QUS is a pertinent technique to assess low bone mass in these patients.

The…[Read more]

The described experimental facts are briefly discussed on the basis of the application of different constitutive molecular or phenomenological rheological models.Mild behavioral impairment (MBI) is a neurobehavioral syndrome characterized by later life emergence of sustained neuropsychiatric symptoms, as an at-risk state for incident cognitive…[Read more]

Background The default mode network (DMN) is a prominent intrinsic network that is observable in many mammalian brains. However, a few studies have investigated the temporal dynamics of this network based on direct physiological recordings. Methods Herein, we addressed this issue by characterizing the dynamics of local field potentials from the…[Read more]

Liver splitting allows the opportunity to share a deceased graft between 2 recipients but remains underutilized. We hypothesized that liver splitting during continuous dual hypothermic oxygenated machine perfusion (DHOPE) is feasible, with shortened total cold ischemia times and improved logistics. Here, we describe a left lateral segment (LLS)…[Read more]

The global emergence of zoonotic viruses, including poxviruses, poses one of the greatest threats to human and animal health. Forty years after the eradication of smallpox, emerging zoonotic orthopoxviruses, such as monkeypox, cowpox, and vaccinia viruses continue to infect humans as well as wild and domestic animals. Currently, the geographical…[Read more]

Exercise restriction is a nonpharmacological treatment of pericarditis that could reduce symptoms by slowing heart rate (HR). Beta-blockers allow pharmacological control of HR. Aim of this paper is to explore the possible efficacy of beta-blockers to improve control of symptoms in patients with pericarditis. We analyzed consecutive cases with…[Read more]

Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have demonstrated antitumor effects in patients with various malignancies, including esophageal cancer. Thus, a better understanding of local immunity in esophageal cancer is crucial for improving treatment and clinical outcomes.

We evaluated PD-1 expression on TILs, as well as…[Read more]