Urquhart Bak

Low-density lipoprotein receptor-related protein-1 (LRP1) is a large endocytic and signaling receptor belonging to the LDL receptor (LDLR) gene family and that is widely expressed in several tissues. LRP1 comprises a large extracellular domain (ECD; 515 kDa, α chain) and a small intracellular domain (ICD; 85 kDa, β chain). The deletion of LRP1 l…[Read more]

sumers are not misled about the risks and benefits of CBD use.Purpose No prior study has been published on suicide-related behaviors among gay, bisexual, transgender, and queer (GBTQ) men in Singapore, where sexual relations between men are criminalized. This study explores the association and mediational pathways between experienced homophobia…[Read more]

Demonstrating inter-device reliability is essential to use devices interchangeably, and accurately integrate, interpret, or compare data from different actigraphs. Despite this, there is a paucity of comparative literature over a timeframe exceeding one night. The aims of this study were to determine an optimal wake threshold for GENEActiv and to…[Read more]

GABAA receptors (GABAARs) mediate inhibitory neurotransmission in the mammalian brain. Recently, numerous GABAAR static structures have been published, but the molecular mechanisms of receptor activation remain elusive. Adavivint mouse Loop G is a rigid β-strand belonging to an extensive β-sheet that spans the regions involved in GABA binding a…[Read more]

Melflufen, a substrate of aminopeptidase B, efficiently eliminates bortezomib-resistant myeloma cells in vitro and in vivo, and completely suppresses clonogenic myeloma growth in vitro at subphysiological concentrations. Thus, melflufen represents a novel treatment option that is able to eradicate drug-resistant myeloma clones characterized by…[Read more]

The purpose of this study was to evaluate the time to medication administration, clinical effect, and safety of a recent Pharmacy and Therapeutics Committee-approved change in the administration of levetiracetam from intravenous piggyback (IVPB) over 15min to undiluted intravenous push (IVP) over 2-5min at a large academic medical center.…[Read more]

Asthma-chronic obstructive pulmonary (COPD) overlap (ACO) coexists with asthma and COPD syndrome characteristics, with more frequent exacerbations, heavier disease burden, higher medical utilization, and even lower quality of life. However, the ACO standard medications supported by evidence-based medicine have not yet appeared.

By using an…[Read more]

05). The median survival time of patients receiving radiotherapy alone was 9months in the LD group and 15months in the HD group (P < 0.05). The survival rate of patients treated with chemoradiotherapy was higher than that of patients treated with radiotherapy alone in the LD group. However, chemoradiotherapy showed no advantage over rad…[Read more]

In this article, carbon microspheres (CMSs) synthesized by the hydrothermal method and CMSs-Fe (with Fe3+ adsorbed on the surface of CMSs) were combined with ammonium polyphosphate (APP) to achieve the fire safety improvement of thermoplastic polyurethane (TPU). The fire safety performance of TPU composites was investigated by the cone calorimeter…[Read more]

In a series of weighted linear regressions and formal tests of mediation, we observed a significant genotype-phenotype association that was partially attenuated after including individual education to the baseline model, although little reductions were observed for household wealth or census tract-level percent poverty. These findings suggest that…[Read more]

2%) and witnessing community violence (73.5%) were the most reported intra-familial ACEs. Males had higher rates of exposure to social violence than females. The most common risky behavior was internet addiction (50%, 95%CI = [47.9-52.3%]). Our survey revealed that ACEs score predict problematic behaviors through impulsiveness (% mediated =…[Read more]