McCain Goodwin

The optimal therapy beyond anthracyclines remains a challenge, especially given the heterogeneity that grouping multiple sts subtypes within clinical trials creates. However, increasing numbers of agents are being studied, and several studies had shown isolated benefit in progression-free or overall survival. Summary First-line systemic therapy…[Read more]

V.Although stimuli that are associated often overlap in time, previous events can also predict the occurrence of a later aversive stimulus and be associated with it to better guide future behavior. Associations of stimuli separated in time have been studied using discrete stimulus as the conditioned stimulus (CS) in trace conditioning or, more…[Read more]

Objective Irrigant activation has been claimed to be beneficial in in vitro and clinical studies. This systematic review aims to investigate the clinical efficiency of mechanically activated irrigants and conventional irrigation. Methods A literature search (PROSPERO registration number CRD42018112595) was undertaken in PubMed, Cochrane and hand…[Read more]

BACKGROUND AND OBJECTIVES Stroke is a chronic, complex condition that disproportionally affects older adults. Health systems are evaluating innovative transitional care (TC) models to improve outcomes in these patients. The Comprehensive Post-Acute Stroke Services (COMPASS) Study, a large cluster-randomized pragmatic trial, tested a TC model for…[Read more]

This study has demonstrated that intratympanic administration of DB-020 results in nominal systemic increases in thiosulfate levels, hence it should not compromise cisplatin anti-tumor efficacy. Furthermore, DB-020 was safe and well tolerated with most adverse events reported as transient, of mild-to-moderate severity and related to the IT…[Read more]

Finally, we detected the loss of a X chromosome in two oocytes derived from women belonging to the ≥35 years age group. These aneuploidies may be caused by the detriment of REEP4, an endoplasmic reticulum protein, in women aged ≥35 years. Here we gained new insight into the complex regulatory circuit between the oocyte and the surrounding CCs and…[Read more]

The instrumentation has been uncoupled from the vehicle’s frame with a system including a Proportional Integral Derivative (PID) controller, studied to maintain the system at a fixed distance from the ground and to reduce damping. The stabilization of this device and the measurement system itself are evaluated and compared to the traditional…[Read more]

/downstream navigation, manual/autonomous drive, and drone turning, that represent a ground truth for validation purposes. Finally, the real-world nature of the dataset makes it more challenging for machine learning methods because it contains noisy samples collected while the drone was exposed to atmospheric agents and uncertain water flow…[Read more]

An evaluation method for assessing the difference in the relative humidity (RH) control performance of waterproofing material is proposed. For a demonstration of this evaluation method, two waterproofing materials (urethane coating and cementitious waterproofing material) installed with different methods (positive and negative side of concrete…[Read more]

Rather, motor imagery alone can sufficiently explain the observed effects in both AO+MI conditions. This bears clear implications for the application of AO+MI procedures in sport and neurorehabilitation. Attachment theory, developed by Mary Ainsworth and John Bowlby about seventy years ago, has become one of the most influential and comprehensive…[Read more]