Lynn Cherry

We further combined NC-specific deletion of Pax3 with the constitutive Pax3Sp-d allele in an effort to generate viable Pax3 mutants to examine later stages of bladder innervation and postnatal bladder function. Neural crest specific deletion of a Pax3 flox allele, using a Sox10-cre driver, in combination with a constitutive Pax3Sp-d mutation…[Read more]

growth, and Pn, thereby alleviating the deleterious effects of NaCl stress on beach plum growth.The alkylating agent, temozolomide (TMZ), is the most commonly used chemotherapeutic for the treatment of glioblastoma (GBM). The anti-glioma effect of TMZ involves a complex response that includes G2-M cell cycle arrest and cyclin-dependent kinase 1…[Read more]

f these symptoms and improve the quality of life of COVID-19 survivors.

Dizziness is a relatively common symptom among patients who call for the emergency medical services (EMS).

To identify factors of importance for the early identification of a time-sensitive condition behind the symptom of dizziness among patients assessed by the…[Read more]

Curative radiotherapy for nasopharyngeal carcinoma (NPC) can lead to acquired nasal cavity stenosis and atresia (ANCSA). As the first study to investigate risk factors of ANCSA in a large cohort of NPC patients, this article aims to develop and validate a multivariate normal tissue complication probability (NTCP) model to predict the development…[Read more]

Hypertension and diabetes are the greatest factors influencing the progression of chronic kidney disease (CKD). Investigation into the role of nephron number in CKD alone or with hypertension has revealed a strong inverse relationship between the two; however, not much is known about the connection between nephron number and diabetic kidney…[Read more]

is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to

infection has not been studied on a large-scale.

A total of 1,160

infection cases and 15,304 controls were identified by applying the eMERGE

infection algorithm to electronic health record data. A genome-wide association…[Read more]

Consistently, Nav1.1 was found reduced by proteomic analysis that revealed abnormality in synapses and metabolic pathways. Our findings describe a role of neddylation in maintaining Nav1.1 stability for PVIN excitability and reveal what we believe is a new mechanism in the pathogenesis of epilepsy.Gene replacement for Duchenne muscular dystrophy…[Read more]