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e existing clinical procedure was stressed. The individualized strategy has helped clinicians reach a great result of terms of glycemic and BP, as well as patient satisfaction. The need for more work to clarify the long-term effect of organized strategy in enhancing the consistency of T2DM treatment in the UAE. The findings also showed increase community pharmacy services may further change the opinions of patients on the level of care provided from such pharmacies. The patients’ quality of life would improve by drug treatment efficacy and pharmacist services to mitigate diabetes complications.

This systematic review reported beneficial pharmacist-led diabetic management services in UAE. Several care strategies also highlighted to improve service for type 2 diabetes mellitus patients.

This systematic review reported beneficial pharmacist-led diabetic management services in UAE. Several care strategies also highlighted to improve service for type 2 diabetes mellitus patients.Behçet’s disease (BD) is a rare systemic vasculitis of unknown etiology with relapsing and remitting course, characterized by triple-symptom complex of recurrent attacks of oral aphthous ulcers, genital ulcers and ocular lesions and other clinical features that include dermatological, cardiovascular, gastrointestinal, and neurological manifestations. The main goal of management is to prevent relapses and to suppress inflammation rapidly for major organ involvement that may cause damage and even be fatal. We hereby describe a case of patient with Behçet’s disease followed in our rheumatology consultation over the course of 15 years with multi-organ involvement that was resistant to several treatments and showed partial results with IL-1 inhibitors, particularly anakinra and canakinumab, while also discussing the current treatments of refractory BD and how early implementation of treatments could make a difference.The Phosphorus-containing heterocycles are an important class of compounds in organic chemistry. Because of their potential application in many fields, especially the synthetic pesticides, medicine and catalyst, the Phosphorus-containing heterocycles have attracted continuous attention by organic synthesis scientists. The development of efficient and low-cost catalytic systems is great interest for construction heterocycles C-P bond. Usually, the Phosphorus-containing heterocycles is prepared via direct carbon-hydrogen (C-H) bond activation or pre-functionalized of heterocycles with carbon-hydrogen （ P-H） bond of phosphorus compounds reaction by metal-catalyzed. This review summarizes recent progress in the heterocycles C-P bond formation reactions by metal-catalyzed, which mainly focusing on the discussion of the reaction mechanism. Aims to provide efficient methods for the future synthesis and application in this field.A novel coronavirus termed nCoV-2019 caused an epidemic of acute respiratory syndrome in humans was first detected in Wuhan, China, in December 2019. nCoV-2019 resulted in thousands of cases of lethal disease all around the world. Unfortunately, there is no specific treatment yet so better understanding of the pathobiology of the disease can be helpful. The renin-angiotensin system and their products has several important physiological actions, On the other hand, this system involved in the pathogenesis of various diseases. In this context, this review article will briefly insights for understanding the role of angiotensin-converting enzyme 2 (ACE2) receptor as a potential attractive target for nCoV-2019- induced acute respiratory syndrome.Memory remains an obligatory regime of human brain and impaired memory causes serious obstacles in our everyday life. Alzheimer’s disease (AD) is one such neurodegenerative disease which is mostly affects elderly population, above the age of 60; marked by cognitive impairment of memory. SGC-CBP30 in vivo Besides the known targets of AD against the several etiologies known till date, the zone of epigenetics has recently evolved as an ingenious field in AD. Epigenetic modifications do not affect DNA sequence but only long-term gene expression. Considering the multifactorial complex nature of AD, we herein discuss the various epigenetic targets which might give rise to potential therapeutic approaches. We reviewed the possible epigenetic targets for AD like HDAC, Sirtuins, glial cells, miRNA and epigenetic modifications like DNA methylation. A deeper insight into these target areas can surely evolve AD diagnosis and therapeutics.

Early in December 2019, a mass of sufferers with Novel Coronavirus Pneumonia (SAS-CoV-19) in Wuhan (China) roused worldwide concern. Hardly any drugs showed the light of hope concerning the depletion in the period of treatment and virological suppression is troubled. Furthermore, numerous sufferers have undergone off-label use or compassionate use treatments as well as antiretroviral, antiparasitic agents, anti-inflammatory compounds, and convales-cent plasma in either oral/parenteral route. This study aims to compile and analyze the efficient value of Remdesivir and Hydroxychloroquine and give an insight to their drug profile in the treatment and management of COVID-19 patients.

The literature search from PubMed, Crossref, Springer, Bentham Sciences, Google Scholar, DOAJ, ScienceDirect, and MEDLINE by using keywords like COVID-19, SAS-COV-2, Remdesivir, and hydroxychloroquine was done and ap-propriate peer-reviewed review articles, as well as research articles, were included and compiled in this review paper. The figures were prepared by using ChemOffice 2016 (ChemDraw Professional 2016) and Microsoft Office.

The results of this study indicate that remdesivir in 5/10 studies from collected literature show a reduction in time of recovery and 5/10 shows no variance and having limitations. However, 6/12 shows an increase in the survival/reduction in time of recovery and 6/12 shows no effect or has limitations in the case of hydroxychloroquine.

There is a need to assess more pharmacokinetics and randomized controlled trials (RCT) for both remdesivir and hydroxychloroquine. Furthermore, studies should be conducted in different combinations along with hydroxychloro-quine and remdesivir to get efficient results.

There is a need to assess more pharmacokinetics and randomized controlled trials (RCT) for both remdesivir and hydroxychloroquine. Furthermore, studies should be conducted in different combinations along with hydroxychloro-quine and remdesivir to get efficient results.