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Our study suggests that embodiment of an outgroup can enhance empathy.Compelling evidence suggests observing iconic gestures benefits learning. While emerging evidence suggests typical iconic gestures benefit comprehension to a greater extent than atypical iconic gestures, it is unclear precisely when and for whom these gestures will be most helpful. The current study investigated factors that may moderate when and for whom gesture benefits narrative comprehension most, including the type of gesture, task difficulty, and individual differences in cognitive ability. Participants were shown a video narrative in which they observed either typical gestures (commonly produced gestures, highly semantically related to accompanying speech), atypical gestures (gestures that are seldom produced), or no gestures. The video narrative was either viewed with interference (background noise to increase task difficulty) or no interference (no background noise). To determine whether the effects of gesture observation and externally imposed task difficulty on narrative comprehension further depend on an individual’s cognitive abilities, participants completed four measures of cognitive abilities (immediate and delayed non-verbal memory, attention, and intellectual ability). Observing typical gestures significantly benefitted narrative comprehension compared with atypical and no gestures combined, which did not differ significantly. Participants with below average and average levels of delayed non-verbal memory benefitted more from typical gestures than atypical or no gestures compared with those with an above average level of delayed non-verbal memory. However, this interaction was only significant when the task was difficult (i.e., with interference) but not when the task was simple (i.e., no interference). This finding suggests that the type of iconic gesture observed may affect gesture’s beneficial effect on narrative comprehension, and that such gestures may be more beneficial in difficult tasks, but only for certain individuals.Some people report localised pain on their body when seeing other people in pain (sensory-localised vicarious pain responders). In this study, we assess whether this is related to atypical computations of body ownership which, in paradigms such as the rubber hand illusion (RHI), can be conceptualised as a Bayesian inference as to whether multiple sources of sensory information (visual, somatosensory) belong together on a single body (one’s own) or are distributed across several bodies (vision = other, somatosensory = self). According to this model, computations of body ownership depend on the degree (and precision) of sensory evidence, rather than synchrony per se. Sensory-localised vicarious pain responders exhibit the RHI following synchronous stroking and-unusually-also after asynchronous stroking. Importantly, this occurs only in asynchronous conditions in which the stroking is predictable (alternating) rather than unpredictable (random). There was no evidence that their bottom-up proprioceptive signals are less precise, suggesting individual differences in the top-down weighting of sensory evidence. Finally, the enfacement illusion (EI) was also employed as a conceptually related bodily illusion paradigm that involves a completely different response judgement (based on vision rather than proprioception). Sensory-localised responders show a comparable pattern on this task after synchronous and asynchronous stroking. This is consistent with the idea that they have top-down (prior) differences in the way body ownership is inferred that transcends the exact judgement being made (visual or proprioceptive).The normalisation model of attention (NMoA) predicts that the attention gain pattern is mediated by changes in the size of the attentional field and stimuli. However, existing studies have not measured gain patterns when the relative sizes of stimuli are changed. To investigate the NMoA, the present study manipulated the attentional field size, namely, the exogenous cue size. Moreover, we assessed whether the relative rather than the absolute size of the attentional field matters, either by holding the target size constant and changing the cue size (Experiments 1-3) or by holding the cue size constant and changing the target size (Experiment 4), in a spatial cueing paradigm of psychophysical procedures. The results show that the gain modulations changed from response gain to contrast gain when the precue size changed from small to large relative to the target size (Experiments 1-3). Moreover, when the target size was once again made larger than the precue size, there was still a change in response gain (Experiment 4). These results suggest that the size of exogenous cues plays an important role in adjusting the attentional field and that relative changes rather than absolute changes to exogenous cue size determine gain modulation. These results are consistent with the prediction of the NMoA and provide novel insights into gain modulations of visual selective attention.Surface-based biophysical methods for measuring binding kinetics of molecular interactions, such as surface plasmon resonance (SPR) or grating-coupled interferometry (GCI), are now well established and widely used in drug discovery. Increasing throughput is an often-cited need in the drug discovery process and this has been achieved with new instrument generations where multiple interactions are measured in parallel, shortening the total measurement times and enabling new application areas within the field. Here, we present the development of a novel technology called waveRAPID for a further-up to 10-fold-increase in throughput, consisting of an injection method using a single sample. MYCi361 Instead of sequentially injecting increasing analyte concentrations for constant durations, the analyte is injected at a single concentration in short pulses of increasing durations. A major advantage of the new method is its ability to determine kinetics from a single well of a microtiter plate, making it uniquely suitable for kinetic screening. We present the fundamentals of this approach using a small-molecule model system for experimental validation and comparing kinetic parameters to traditional methods. By varying experimental conditions, we furthermore assess the robustness of this new technique. Finally, we discuss its potential for improving hit quality and shortening cycle times in the areas of fragment screening, low-molecular-weight compound screening, and hit-to-lead optimization.