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Purpose For bilaterally implanted patients, the automatic gain control (AGC) in both left and right cochlear implant (CI) processors is usually neither linked nor synchronized. At high AGC compression ratios, this lack of coordination between the two processors can distort interaural level differences, the only useful interaural difference cue available to CI patients. This study assessed the improvement, if any, in the utility of interaural level differences for sound source localization in the frontal hemifield when AGCs were synchronized versus independent and when listeners were stationary versus allowed to move their heads. Method Sound source identification of broadband noise stimuli was tested for seven bilateral CI patients using 13 loudspeakers in the frontal hemifield, under conditions where AGCs were linked and unlinked. For half the conditions, patients remained stationary; in the other half, they were encouraged to rotate or reorient their heads within a range of approximately ± 30° during sound presentation. Results In general, those listeners who already localized reasonably well with independent AGCs gained the least from AGC synchronization, perhaps because there was less room for improvement. Those listeners who performed worst with independent AGCs gained the most from synchronization. All listeners performed as well or better with synchronization than without; however, intersubject variability was high. Head movements had little impact on the effectiveness of synchronization of AGCs. Conclusion Synchronization of AGCs offers one promising strategy for improving localization performance in the frontal hemifield for bilaterally implanted CI patients. Supplemental Material https//doi.org/10.23641/asha.14681412.

The aim of this study was to evaluate the performance of the new classification of urinary tract dilatation (UTD) to predict long-term clinical outcomes in infants with isolated antenatal hydronephrosis (ANH).

Between 1989 and 2019, 447 infants diagnosed with isolated severe ANH and were prospectively followed. The main predictive variable for the analysis was the new UTD classification system. The events of interest were surgical interventions, urinary tract infections, chronic kidney disease stage II or higher, hypertension and proteinuria. The primary end-point was time until the occurrence of a composite event of renal injury, including proteinuria, hypertension and chronic kidney disease.

Among 447 infants with ANH included in the analysis, 255 (57%) had UTD P1, 93 (20.8%) UTD P2 and 99 (22.2%) UTD P3. Median followup time was 9 years (IQR 7-12 years). Of 447 patients included in the analysis, 11 (2.5%) had hypertension, 13 (2.9%) exhibited persistent mild proteinuria, 14 (3%) developed chronic kidney disease Stage 2 and 26 (5.8%) had the composite outcome of renal injury. By survival analysis, the UTD system predicted accurately all events of interest. According to the Kaplan-Meier survival analysis, the probability of renal injury at 20 years of age was estimated at about 0%, 14% and 56% for patients assigned to UTD P1, UTD P2 and UTD P3, respectively (p <0.001).

Our findings provide insights that the new UTD classification has a good performance for discriminating not only mid-term, but also long-term clinical outcomes, including renal injury.

Our findings provide insights that the new UTD classification has a good performance for discriminating not only mid-term, but also long-term clinical outcomes, including renal injury.We have developed the two-body coupled-rotator slowly relaxing local structure (SRLS) approach for elucidating protein dynamics by nuclear magnetic resonance (NMR) relaxation. The rotators are represented by diffusion tensors D1 for overall protein tumbling and D2 for locally ordered probe motion. D1 and D2 are coupled dynamically by a potential, u, typically given by linear combinations of the Wigner functions D002 and (D022 + D0-22). Until now, our SRLS analyses provided the tensors, D1 and D2, the potential, u, and the geometric link between SRLS and NMR. Here we enhance this description by also examining the SRLS spectral densities obtained by solving the SRLS Smoluchowski equation. In addition, we show that the form of u specified above complies with two NMR-detected potential energy landscapes representing preferential ordering along N-H or Cα-Cα. Pictorial illustrations thereof are provided. The extended SRLS analysis is applied to 15N-H relaxation from the carbohydrate recognition domain of galectin-3 (Gal3C) in complex with two diastereomeric ligands, S and R. Momelotinib price We find that D2 is isotropic with a principal value, D2, of 1010 s-1 on average, and it is faster in the strands β3, β5, and β8. The potential, u, is strong (∼20 kT); it is slightly rhombic when N-H is the main ordering axis and highly rhombic when Cα-Cα is the main ordering axis. Gal3C-S exhibits primarily preferential ordering along Cα-Cα; Gal3C-R exhibits both types of ordering. The binding-associated polypeptide chain segment of Gal3C-S is homogeneous, whereas that of Gal3C-R is diversified, with regard to D2 and ordering preference. We associate these features with the previously determined diminished binding constant of Gal3C-R in comparison with Gal3C-S. Thus, the present study enhances the SRLS analysis, in general, and provides new insights into the dynamic structure and binding properties of Gal3C-S and Gal3C-R, in particular.The use of bicyclo[1.1.1]pentanes (BCPs) as para-disubstituted aryl bioisosteres has gained considerable momentum in drug development programs. Carbon-carbon bond formation via transition-metal-mediated cross-coupling represents an attractive strategy to generate BCP-aryl compounds for late-stage functionalization, but these typically require reactive organometallics to prepare BCP nucleophiles on demand from [1.1.1]propellane. In this study, the synthesis and Ni-catalyzed functionalization of BCP redox-active esters with (hetero)aryl bromides via the action of a photoactive electron donor-acceptor complex are reported.Magnetic microscopy that combines nanoscale spatial resolution with picosecond scale temporal resolution uniquely enables direct observation of the spatiotemporal magnetic phenomena that are relevant to future high-speed, high-density magnetic storage and logic technologies. Magnetic microscopes that combine these metrics has been limited to facility-level instruments. To address this gap in lab-accessible spatiotemporal imaging, we develop a time-resolved near-field magnetic microscope based on magnetothermal interactions. We demonstrate both magnetization and current density imaging modalities, each with spatial resolution that far surpasses the optical diffraction limit. In addition, we study the near-field and time-resolved characteristics of our signal and find that our instrument possesses a spatial resolution on the scale of 100 nm and a temporal resolution below 100 ps. Our results demonstrate an accessible and comparatively low-cost approach to nanoscale spatiotemporal magnetic microscopy in a table-top form to aid the science and technology of dynamic magnetic devices with complex spin textures.