Activity

Higher plasma exposure and amount of imeglimin renally excreted in moderate hepatic impaired subjects, associated with an unchanged elimination rate, suggests that this increase could be linked to a higher oral absorption and/or lower hepatic uptake in this population.

Imeglimin was safe and well tolerated in all subjects.

EudraCT 2018-001950-83.

EudraCT 2018-001950-83.The sunk-cost effect (SCE) is the tendency to continue investing in something that is not working out because of previous investments that cannot be recovered. In three experiments, we examine the SCE when continued investment violates the ethic of care by harming others. In Experiment 1, the SCE was smaller if the sunk-cost decision resulted in harmful consequences towards others (an interaction between sunk cost and the ethic of care). In Experiment 2, participants considered vignettes from their own or another person’s perspective. We observed an interpersonal SCE – people showed the SCE when taking the perspective of others. We did not replicate the interaction found in Experiment 1. In Experiment 3, we used statistically more powerful analyses – Bayesian sequential hypothesis testing – to examine the interaction between sunk cost and the ethic of care. We found evidence in favor of the interaction; the SCE was smaller if the sunk-cost decision harmed others. We suggest that violating one’s ethic of care de-biases decision-making by overshadowing sunk costs. These findings may help explain decision-making in real-world situations involving large investments.Apoptosis is a highly conserved physiological process of programmed cell death which is critical for proper organism development, tissue maintenance, and overall organism homeostasis. Proper regulation of cell removal is crucial, as both excessive and reduced apoptotic rates can lead to the onset of a variety of diseases. Apoptosis can be induced in cells in response to biochemical, electrical, and mechanical stimuli. Here, we review literature on specific mechanical stimuli that regulate apoptosis and the current understanding of how mechanotransduction plays a role in apoptotic signaling. We focus on how insufficient or excessive mechanical forces may induce apoptosis in the cardiovascular system and thus contribute to cardiovascular disease. Although studies have demonstrated that a broad range of mechanical stimuli initiate and/or potentiate apoptosis, they are predominantly correlative, and no mechanisms have been established. In this review, we attempt to establish a unifying mechanism for how various mechanical stimuli initiate a single cellular response, i.e. apoptosis. We hypothesize that the cytoskeleton plays a central role in this process as it does in determining myriad cell behaviors in response to mechanical inputs. We also describe potential approaches of using mechanomedicines to treat various diseases by altering apoptotic rates in specific cells. The goal of this review is to summarize the current state of the mechanobiology field and suggest potential avenues where future research can explore.In this study, growth performance, body composition, digestive enzymes activity, mucosal and immunological parameters, cultivable bacterial populations, and stress resistance were investigated in juvenile convict cichlid fish (Amatitlania nigrofasciata) that received a dietary supplement containing 0 (control), 5 × 106 (LC1), 5 × 107 (LC2), and 5 × 108 CFU g-1 diet (LC3) Lacticaseibacillus casei PB-LC39. Two hundred and forty fish (2.44 ± 0.04 g) were assigned to twelve experimental aquariums and feed ad libitum three times a day for 8 weeks. After final sampling, final body weight, percentage of weight gain (WG %), specific growth rate (SGR), food conversion ratio (FCR), and protein content of whole-body composition were significantly higher (P less then 0.05) in fish fed LC1 diet than other treatments. Total protease, amylase, and lipase activities were also significantly higher (P less then 0.05) in fish fed LC1 diet than other groups. Total protein from serum and mucus, lysozyme activity, total immunoglobulin (Ig), and serum globulin were significantly increased (P less then 0.05) in fish fed LC1 diet compared with other groups. Moreover, total counts of lactic acid bacteria (LAB) in fish gut were significantly higher (P less then 0.05) by different levels of L. casei PB-LC39 than the control group. Recovery rates of fish fed the probiotic cells, after an air-dive test, was significantly increased (P less then 0.05) compared with the control group. Therefore, the results showed that L. casei PB-LC39 resulted in improving growth, health status, and stress resistance of fish during the rearing of juvenile convict cichlid fish.Celiac disease (CD) is a chronic autoimmune disease that occurs in genetically predisposed individuals. Gluten-hydrolyzing probiotic bacteria are promising for alleviating symptoms in individuals with CD. Therefore, in this study, the gluten hydrolysis ability and probiotic potential of Lact. brevis KT16-2 were determined. Lact. brevis KT16-2 formed proteolysis zones on gluten and gliadin agar plates, in which gluten and gliadin were used as the only nitrogen sources. SDS-PAGE analysis showed that Lact. brevis KT16-2 completely hydrolyzed peptides ranging from 28 to 66 kDa in 8 h. Then, the survival of the strain in bile salts, in simulated gastric juice and at low pH was determined. Additionally, the antioxidant and antimicrobial substance production, autoaggregation, hydrophobicity and antibiotic resistance of the strain were investigated. API-ZYM test kits were used to determine the enzymatic capacity of the strain. Lact. this website brevis KT16-2 had the ability to hydrolyze wheat gluten. It was able to survive in a broad pH range (pH 2-8), in bile salts (0.3-1%), and in simulated gastric juice. It had the ability to autoaggregate (59.4%), and the hydrophobicity (52.7%) of the strain was determined. In addition, this strain was capable of producing antimicrobial peptides against test bacteria, including antibiotic-resistant bacteria. Cell-free supernatants (CFS) of the strain had high antioxidant activity (DPPH-71.0% and ABTS-54.1%). The results of this study suggest that Lact. brevis KT16-2, which can hydrolyze gliadin and has many essential probiotic properties, has the potential to be used as a probiotic supplement for individuals with CD.