Activity

ETHNOPHARMACOLOGICAL RELEVANCE Sauropus androgynus L. Merr is an underexploited perennial shrub traditionally used as a medicinal plant in South Asia and Southeast Asia. The plant is regarded as not just a green vegetable for diet but a traditional herb for certain aliments. For instance, it has traditionally been used to relieve fever, to treat ulcers and diabetes, to promote lactation and eyesight, as well as reducing obesity. AIM OF THE STUDY This paper aims to review the botany, phytochemistry, ethnopharmacology and pharmacological activities of S. androgynus and discuss the known chemical constituents combined with S. androgynus-induced bronchiolitis obliterans for providing new ideas to the following mechanism of the disease and pharmacology research of the plant. MATERIALS AND METHODS The data presented in this review were collected from published literatures as well as the electronic databases of PubMed, CNKI, Web of Science, SCI finder, ACS, Science Direct, Wiley, Springer, Taylor, Google Scholar and and side effects of the plant presently used in health care and medicine are a major area of concern. CONCLUSION Though little importance of this multigreen plant was attached, S. androgynus has notable phytochemical constituents and various pharmacological activities including antioxidant, anti-inflammatory, anti-obesity activities. Studies have firmly established the association between excessive consumption of the uncooked S. androgynus juice over a period of time and the occurrence of bronchiolitis obliterans. It is unsuited to ingestion of excessive S. androgynous before fully understanding the pathogenesis and induction mechanism of this fatal disease. S. androgynus-induced bronchiolitis obliterans, phytochemistry together with of pharmacology for traditional uses of S. androgynus still needed further investigation. V.ETHNOPHARMACOLOGICAL RELEVANCE Sophora alopecuroides L. is one of the most commonly used plants in traditional medicine for the management conditions including inflammatory and gastrointestinal disease. However, the therapeutic mechanism of Sophora alopecuroides L.particularly in inflammatory bowel disease (IBD) remains unclear. AIM OF THE STUDY To evaluate the treatment effects of total alkaloids of Sophora alopecuroides L. in ulcerative colitis (UC) mice model and explore the therapeutic mechanism of KDZ on UC based on bile acid metabolism and gut microbiota. MATERIALS AND METHODS Colitis were induced in BALB/c mice by administering 3.5% dextran sulfate sodium (DSS) in drinking water for 7 days. The mice were then given KDZ (300, 150 and 75 mg/kg) and the positive drug sulfasalazine (SASP, 450 mg/kg) via oral administration for 7 days. The levels of 23 bile acids in the liver, bile, serum, cecum content and colon were determined through ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-ETHNOPHARMACOLOGICAL RELEVANCE Vernonia anthelmintica (L.) Willd. (Asteraceae; Purple Fleabane) has a long history of traditional use for the management of several disorders related to skin, central nervous system, kidney, gynecology, gastrointestinal, metabolism, and general health. The review aims to provide updated systematic information on ethnomedicinal uses, phytochemistry, pharmacological uses, toxicity studies, and patented formulations of V. anthelmintica. This review will not only help to identify the research gaps but also provide information to the scientific community for future research requisites. MATERIAL AND METHODS Empirical searches were conducted on the medicinal plant via significant search engines like Google Scholar, Scopus-Elsevier, Medline, SciFinder, Web of Science, Directory of Open Access Journal (DOAJ) from inception until June 2018. Besides, references from local literature, books, and non-English journals were also included. RESULTS Scientific reports revealed that V. anthelmintowever, further studies are needed to explore the exact mechanism of action, pharmacokinetics, chronic toxicological studies, safe dose consumption, and possible interactions with other herbs. V.BACKGROUND Conventional histological analyses are the gold standard for the study of aneurysms and vascular pathologies in pre-clinical research. Over the past decade, in vivo and ex vivo imaging using multiphoton microscopy have emerged as powerful pre-clinical tools for detailed tissue analyses that can assess morphology, the extracellular matrix (ECM), cell density and vascularisation. Multiphoton microscopy allows for deeper tissue penetration with minor phototoxicity. ML-7 research buy OBJECTIVE The present study aimed to demonstrate the current status of multimodality imaging, including multiphoton microscopy, for detailed analyses of neo-endothelialisation and ECM evolution after flow-diverter stent (FDS) treatment in an experimental rabbit model of aneurysms. METHODS Multiphoton microscopy tools for assessing autofluorescence and second harmonic generation (SHG) signals from biological tissues were used to evaluate the endovascular treatment of intracranial aneurysms in an animal model of aneurysms (pig, rabbit). Results from multiphoton microscopy were compared to those from standard histology, electronic and bright field microscopy. CONCLUSIONS The present study describes novel evaluation modes based on multiphoton microscopy for visualising tissue morphology (e.g., collagen, elastin, and cells) to qualify and quantify the extent of neo-intimal formation of covered arteries and device integration into the arterial wall using a rabbit model of intracranial aneurysms treated with FDS. PURPOSE To assess efficacy, safety and to discuss optimal medical therapy of stent-assisted coiling of ruptured intracranial aneurysms. METHODS Ruptured intracranial aneurysms treated with stent-assisted coiling in eight different institutions were retrospectively reviewed. Medical treatment regimens varied among the centers, mainly regarding heparin administration and post-procedural single or double antiplatelet therapy. Clinical and angiographic results, including complications and outcomes were analyzed and related to the different therapies. RESULTS Sixty-one consecutive patients (male/female 23/38), aged 59.1 years (36-86) underwent stent-assisted coiling for ruptured intracranial aneurysm without antiplatelet pre-medication. Intravenous acetylsalicylic acid (ASA) 500mg was administered to all patients immediately after stent deployment. At the same time heparin was given as bolus in 15 patients (24.6%) as part of local protocol. Intravenous glycoprotein 2b/3a inhibitors (antiGP2b3a) were used as bail-out therapy for stent thrombosis.